Beilstein J. Org. Chem.2021,17, 2399–2416, doi:10.3762/bjoc.17.157
, brevipolides G–I (7–9) were found to inhibit the CCR5 receptor signaling as measured by a calciummobilization assay with IC50 values of 15.5, 13.7, and 18.0 μM, respectively, which make them potential agents for treating HIV disease (Table 2, entries 7–9) [11].
Giménez and co-workers, in 2019, reported the
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Graphical Abstract
Figure 1:
Structures of brevipolides A–O (1 – 15).
Beilstein J. Org. Chem.2015,11, 2689–2695, doi:10.3762/bjoc.11.289
neuronal cells.
Keywords: calciummobilization; cIDPR analogues; cyclic ADP-ribose (cADPR); cyclization; Introduction
Nucleosides and nucleotides (NNs) are widely used as key intermediates and important core structures in the field of synthetic medicinal chemistry [1][2]. They represent versatile
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Graphical Abstract
Figure 1:
Structures of cADPR (1), cIDPR (2), cpIDP (3) and cpIMP (4).